CXCR2 Gα15 CHO
CBP71658
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| I. Background | |
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CXCR2是一种G蛋白偶联趋化因子受体，主要表达于中性粒细胞等免疫细胞表面。它的核心功能是介导中性粒细胞的趋化与活化，是启动炎症反应的关键分子。该受体在多种病理过程中扮演重要角色，包括急性肺损伤、慢性阻塞性肺疾病、缺血再灌注损伤以及癌症等，因此其抑制剂在临床前和临床研究中被广泛评估。 |
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| II. Description | |
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CXCR2 Gα15 CHO 药靶模型很好的模拟了体内 CXCR2的信号转导过程。 |
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| III. Introduction | |
| Host Cell: |
CHO |
| Expressed gene: | CXCR2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5 μg/ml Puromycin+800μg/ml G418 |
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): |
Functional assay for CXCR2 |
| Transducer: | Gi |
| IV. Description of Host Cell Line | |
| Organism: | Hamster |
| Tissue: | Ovary |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| V. Representative Data | |
Figure 1. HTRF IP-One Assay with CXCR2 Gα15 CHO( C23).
Figure 2. HTRF cAMP Assay with CXCR2 Gα15 CHO( C23).
